Transgenic Expression of IL15 Retains CD123-Redirected T Cells in a Less Differentiated State Resulting in Improved Anti-AML Activity in Autologous AML PDX Models

Immunotherapy with T-cells expressing bispecific T-cell engagers (ENG T-cells) is a promising approach to improve the outcomes for patients with recurrent/refractory acute myeloid leukemia (AML). However, similar to T-cells expressing chimeric antigen receptors (CARs), their antitumor activity is li...

Ausführliche Beschreibung

Bibliografische Detailangaben

Hauptverfasser:	Hong Mu-Mosley, Lauren Ostermann, Muharrem Muftuoglu, Abishek Vaidya, Challice L. Bonifant, Mireya Paulina Velasquez, Stephen Gottschalk, Michael Andreeff
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Frontiers Media S.A. 2022-05-01
Schriftenreihe:	Frontiers in Immunology
Schlagworte:	AML T cells immunotherapy IL15 CD123 BiTE
Online-Zugang:	https://www.frontiersin.org/articles/10.3389/fimmu.2022.880108/full
Tags:	Tag hinzufügen Keine Tags, Fügen Sie das erste Tag hinzu!