Myrislignan targets extracellular signal-regulated kinase (ERK) and modulates mitochondrial function to dampen osteoclastogenesis and ovariectomy-induced osteoporosis

Abstract Background Activated osteoclasts cause excessive bone resorption, and disrupt bone homeostasis, leading to osteoporosis. The extracellular signal-regulated kinase (ERK) signaling is the classical pathway related to osteoclast differentiation, and mitochondrial reactive oxygen species are cl...

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Hlavní autoři:	Tao Yang, Weiwei Chen, Kai Gan, Chaofeng Wang, Xiaoxiao Xie, Yuangang Su, Haoyu Lian, Jiake Xu, Jinmin Zhao, Qian Liu
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	BMC 2023-11-01
Edice:	Journal of Translational Medicine
Témata:	ERK Mitochondria Myrislignan LM22B-10 Osteoclast Osteoporosis
On-line přístup:	https://doi.org/10.1186/s12967-023-04706-2
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