Cytokine preactivation and ADCC: a potent strategy for enhancing human NK cell effector functions against 3D tumor models

The adoptive transfer of NK cells has shown clinical promise in hematologic malignancies, but its efficacy in solid tumors remains limited. Three-dimensional (3D) models reproduce tumor architecture and immunosuppressive microenvironments more accurately than conventional two-dimensional (2D) cultur...

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Autors principals:	Ainara Lopez-Pardo, Ainhoa Amarilla-Irusta, Ainhoa Iturbe-Larrondo, Itxaso San Juan, Víctor Sandá, Olatz Zenarruzabeitia, Francesca D Ciccarelli, Francisco Borrego, Laura Amo
Format:	Artigo
Idioma:	Inglês
Publicat:	Frontiers Media S.A. 2026-05-01
Col·lecció:	Frontiers in Immunology
Matèries:	ADCC cetuximab colorectal cancer cytokines immunotherapy lung cancer
Accés en línia:	https://www.frontiersin.org/articles/10.3389/fimmu.2026.1797290/full
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