Cytokine preactivation and ADCC: a potent strategy for enhancing human NK cell effector functions against 3D tumor models

The adoptive transfer of NK cells has shown clinical promise in hematologic malignancies, but its efficacy in solid tumors remains limited. Three-dimensional (3D) models reproduce tumor architecture and immunosuppressive microenvironments more accurately than conventional two-dimensional (2D) cultur...

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Principais autores:	Ainara Lopez-Pardo, Ainhoa Amarilla-Irusta, Ainhoa Iturbe-Larrondo, Itxaso San Juan, Víctor Sandá, Olatz Zenarruzabeitia, Francesca D Ciccarelli, Francisco Borrego, Laura Amo
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Frontiers Media S.A. 2026-05-01
Colecção:	Frontiers in Immunology
Assuntos:	ADCC cetuximab colorectal cancer cytokines immunotherapy lung cancer
Acesso em linha:	https://www.frontiersin.org/articles/10.3389/fimmu.2026.1797290/full
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