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Nuclear actin and DNA replication stress regulate telomere maintenance by telomerase

Abstract The recruitment of telomerase to telomeres is a tightly regulated process which is stimulated by replication stress and the DNA damage response regulatory kinase ATR, via an unknown mechanism. Here, we demonstrate that nuclear filamentous actin is important for the stable interaction of tel...

Whakaahuatanga katoa

I tiakina i:
Ngā taipitopito rārangi puna kōrero
Ngā kaituhi matua: Ashley Harman, Melissa Kartawinata, Nohad M. Maroun, Darren R. Nguyen, Shabita Rahman, William E. Hughes, Kevin Winardi, Scott B. Cohen, Anthony J. Cesare, Noa Lamm, Tracy M. Bryan
Hōputu: Artigo
Reo:Inglês
I whakaputaina: Nature Portfolio 2025-12-01
Rangatū:Nature Communications
Urunga tuihono:https://doi.org/10.1038/s41467-025-66506-0
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