Nuclear actin and DNA replication stress regulate telomere maintenance by telomerase

Abstract The recruitment of telomerase to telomeres is a tightly regulated process which is stimulated by replication stress and the DNA damage response regulatory kinase ATR, via an unknown mechanism. Here, we demonstrate that nuclear filamentous actin is important for the stable interaction of tel...

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Autors principals:	Ashley Harman, Melissa Kartawinata, Nohad M. Maroun, Darren R. Nguyen, Shabita Rahman, William E. Hughes, Kevin Winardi, Scott B. Cohen, Anthony J. Cesare, Noa Lamm, Tracy M. Bryan
Format:	Artigo
Idioma:	Inglês
Publicat:	Nature Portfolio 2025-12-01
Col·lecció:	Nature Communications
Accés en línia:	https://doi.org/10.1038/s41467-025-66506-0
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