Screening helper T lymphocyte epitopes based on IFN-γ/IL-10 ratio for developing a novel multi-epitope vaccine candidate using Wolbachia surface protein as an adjuvant against visceral leishmaniasis

Abstract Background Visceral leishmaniasis (VL) is the most lethal form of leishmaniasis. In terms of anti-leishmanial vaccines, favorable immune responses are Th1 responses that primarily produce interferon gamma (IFN-γ) and activate macrophages for leishmanicidal effects. The selection of IFN-γ-in...

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Номзүйн дэлгэрэнгүй

Үндсэн зохиолчид:	Jianhui Zhang, Tianhang Lv, Shuoyan Tan, Lingqi Yu, Yangjian Chi, Jianping Chen, Xiaohui Fan, Xiaoyan Lu
Формат:	Artigo
Хэл сонгох:	Inglês
Хэвлэсэн:	BMC 2025-03-01
Цуврал:	Parasites & Vectors
Нөхцлүүд:	Leishmania Multi-epitope vaccine Immunoinformatics Wolbachia surface protein Adjuvant
Онлайн хандалт:	https://doi.org/10.1186/s13071-025-06756-5
Шошгууд:	Шошго нэмэх Шошго байхгүй, Энэхүү баримтыг шошголох эхний хүн болох!