Screening helper T lymphocyte epitopes based on IFN-γ/IL-10 ratio for developing a novel multi-epitope vaccine candidate using Wolbachia surface protein as an adjuvant against visceral leishmaniasis

Abstract Background Visceral leishmaniasis (VL) is the most lethal form of leishmaniasis. In terms of anti-leishmanial vaccines, favorable immune responses are Th1 responses that primarily produce interferon gamma (IFN-γ) and activate macrophages for leishmanicidal effects. The selection of IFN-γ-in...

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Autori principali:	Jianhui Zhang, Tianhang Lv, Shuoyan Tan, Lingqi Yu, Yangjian Chi, Jianping Chen, Xiaohui Fan, Xiaoyan Lu
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	BMC 2025-03-01
Serie:	Parasites & Vectors
Soggetti:	Leishmania Multi-epitope vaccine Immunoinformatics Wolbachia surface protein Adjuvant
Accesso online:	https://doi.org/10.1186/s13071-025-06756-5
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