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Longitudinal CNS and systemic T-lymphocyte and monocyte activation before and after antiretroviral therapy beginning in primary HIV infection

BackgroundTrafficking of immune cells to the central nervous system is hypothesized to facilitate HIV entry and immune-induced neuronal injury and is mediated by surface proteins such as chemokine receptors and α4 integrin. We longitudinally assessed immune cell activation and surface marker express...

Ausführliche Beschreibung

Gespeichert in:
Hauptverfasser: Phillip Chan, Xiang Li, Fangyong Li, Brinda Emu, Richard W. Price, Serena Spudich
Format: Artigo
Sprache:Inglês
Veröffentlicht: Frontiers Media S.A. 2025-02-01
Schriftenreihe:Frontiers in Immunology
Schlagworte:
primary HIV infection
antiretroviral therapy
cerebrospinal fluid
T-lymphocyte
monocyte
Online-Zugang:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1531828/full
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