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Longitudinal CNS and systemic T-lymphocyte and monocyte activation before and after antiretroviral therapy beginning in primary HIV infection

BackgroundTrafficking of immune cells to the central nervous system is hypothesized to facilitate HIV entry and immune-induced neuronal injury and is mediated by surface proteins such as chemokine receptors and α4 integrin. We longitudinally assessed immune cell activation and surface marker express...

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Hlavní autoři: Phillip Chan, Xiang Li, Fangyong Li, Brinda Emu, Richard W. Price, Serena Spudich
Médium: Artigo
Jazyk:Inglês
Vydáno: Frontiers Media S.A. 2025-02-01
Edice:Frontiers in Immunology
Témata:
primary HIV infection
antiretroviral therapy
cerebrospinal fluid
T-lymphocyte
monocyte
On-line přístup:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1531828/full
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