Loss of synaptic Munc13-1 underlies neurotransmission abnormalities in spinal muscular atrophy
Abstract Spinal muscular atrophy (SMA) is a devastating neurodegenerative disease characterized by degeneration of spinal motoneurons, leading to muscle atrophy and synaptic loss. SMN functions in mRNA splicing, transport, and local translation are crucial for maintaining synaptic integrity. Within...
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| Autori principali: | , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Springer
2025-08-01
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| Serie: | Cellular and Molecular Life Sciences |
| Soggetti: | |
| Accesso online: | https://doi.org/10.1007/s00018-025-05859-7 |
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