Trabectedin arrests a doxorubicin-resistant PDGFRA-activated liposarcoma patient-derived orthotopic xenograft (PDOX) nude mouse model

Abstract Background Pleomorphic liposarcoma (PLPS) is a rare, heterogeneous and an aggressive variant of liposarcoma. Therefore, individualized therapy is urgently needed. Our recent reports suggest that trabectedin (TRAB) is effective against several patient-derived orthotopic xenograft (PDOX) mous...

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Principais autores:	Tasuku Kiyuna, Yasunori Tome, Takashi Murakami, Kei Kawaguchi, Kentaro Igarashi, Kentaro Miyake, Masuyo Miyake, Yunfeng Li, Scott D. Nelson, Sarah M. Dry, Arun S. Singh, Tara A. Russell, Irmina Elliott, Shree Ram Singh, Fuminori Kanaya, Fritz C. Eilber, Robert M. Hoffman
פורמט:	Artigo
שפה:	Inglês
יצא לאור:	BMC 2018-08-01
סדרה:	BMC Cancer
נושאים:	Liposarcoma Patient-derived orthotopic xenograft PDOX PDGFRA amplification Trabectedin Precision medicine
גישה מקוונת:	http://link.springer.com/article/10.1186/s12885-018-4703-0
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