Trabectedin arrests a doxorubicin-resistant PDGFRA-activated liposarcoma patient-derived orthotopic xenograft (PDOX) nude mouse model

Abstract Background Pleomorphic liposarcoma (PLPS) is a rare, heterogeneous and an aggressive variant of liposarcoma. Therefore, individualized therapy is urgently needed. Our recent reports suggest that trabectedin (TRAB) is effective against several patient-derived orthotopic xenograft (PDOX) mous...

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Detalhes bibliográficos

Principais autores:	Tasuku Kiyuna, Yasunori Tome, Takashi Murakami, Kei Kawaguchi, Kentaro Igarashi, Kentaro Miyake, Masuyo Miyake, Yunfeng Li, Scott D. Nelson, Sarah M. Dry, Arun S. Singh, Tara A. Russell, Irmina Elliott, Shree Ram Singh, Fuminori Kanaya, Fritz C. Eilber, Robert M. Hoffman
Formato:	Artigo
Idioma:	Inglês
Publicado em:	BMC 2018-08-01
coleção:	BMC Cancer
Assuntos:	Liposarcoma Patient-derived orthotopic xenograft PDOX PDGFRA amplification Trabectedin Precision medicine
Acesso em linha:	http://link.springer.com/article/10.1186/s12885-018-4703-0
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