Determination of steroid hydroxylation specificity of an industrial strain Aspergillus ochraceus TCCC41060 by cytochrome P450 gene CYP68J5

Abstract Purpose The use of Aspergillus ochraceus TCCC41060 for synthesis of 11α-OH-ethylgonendione, an important intermediate for synthesis of desogestrel-a major ingredient of the “third-generation” oral contraceptives, is hampered by its low regioselectivity of hydroxylation. In the present study...

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Bibliografski detalji

Glavni autori:	Xue Wang, Xingwei Yang, Xi Jia, Peng Jin, Zhengxiang Wang, Fuping Lu, Xiaoguang Liu
Format:	Artigo
Jezik:	Inglês
Izdano:	BMC 2020-07-01
Serija:	Annals of Microbiology
Teme:	Aspergillus ochraceus Steroid Hydroxylase Cytochrome P450 D-ethylgonendione Glucocorticoids
Online pristup:	https://doi.org/10.1186/s13213-020-01577-6
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