A comparison of commercial assays quantifying mature brain-derived neurotrophic factor (mBDNF) and its precursor (pro-BDNF) in human serum

Abstract Brain-derived neurotrophic factor (BDNF) and its isoforms (pro- and mBDNF) are promising neurobiomarkers. While total serum BDNF levels have been previously validated, the newer isoforms have not. We aimed to identify the most common serum pro- and mBDNF assays through a literature search (...

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Bibliografische Detailangaben

Hauptverfasser:	Alicia Olivas-Martínez, Francisco M. Peinado, Ainhoa Pérez-Cantero, Lydia Espín-Moreno, Andrea Rodríguez-Carrillo, Esther García-Esquinas, Nicolás Olea, Vicente Mustieles, Mariana F. Fernández
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Nature Portfolio 2025-10-01
Schriftenreihe:	Scientific Reports
Schlagworte:	Total BDNF Pro-BDNF MBDNF Serum Effect biomarkers ELISA
Online-Zugang:	https://doi.org/10.1038/s41598-025-22278-7
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