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Enhanced protein secretion in reduced genome strains of Streptomyces lividans

Abstract Background S. lividans TK24 is a popular host for the production of small molecules and the secretion of heterologous protein. Within its large genome, twenty-nine non-essential clusters direct the biosynthesis of secondary metabolites. We had previously constructed ten chassis strains, car...

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Autori principali: Mohamed Belal Hamed, Tobias Busche, Kenneth Simoens, Sebastien Carpentier, Jan Kormanec, Lieve Van Mellaert, Jozef Anné, Joern Kalinowski, Kristel Bernaerts, Spyridoula Karamanou, Anastassios Economou
Natura: Artigo
Lingua:Inglês
Pubblicazione: BMC 2024-01-01
Serie:Microbial Cell Factories
Soggetti:
Reduced genome strains
Secretome
Proteomics
Transcriptomics
Heterologous secretion
Accesso online:https://doi.org/10.1186/s12934-023-02269-x
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