A novel bi-directional promoter system allows tunable recombinant protein production in Pichia pastoris

Abstract Background The methylotrophic yeast Pichia pastoris is a well-studied host organism for recombinant protein production, which is usually regulated either by a constitutive promoter (e.g. promoter of glyceraldehyde-3-phosphate dehydrogenase; PGAP) or an inducible promoter (e.g. promoter of a...

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Autori principali:	Vignesh Rajamanickam, Karl Metzger, Christian Schmid, Oliver Spadiut
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	BMC 2017-09-01
Serie:	Microbial Cell Factories
Soggetti:	Pichia pastoris Bi-directional promoter Bioprocess development Mixed feed Tunable recombinant protein production
Accesso online:	http://link.springer.com/article/10.1186/s12934-017-0768-8
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