Characterization of recombinant human lysosomal beta-hexosaminidases produced in the methylotrophic yeast Pichia pastoris

β-hexosaminidases (Hex) are dimeric enzymes involved in the lysosomal degradation of glycolipids and glycans. They are formed by α- and/or β-subunits encoded byHEXA and HEXB genes, respectively. Mutations in these genes lead to Tay Sachs or Sandhoff diseases, which are neurodegenerative disorders ca...

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Autors principals:	Angela Johana Espejo Mojica, Angela Rocío Mosquera, Edwin Alexander Rodríguez-López, Dennis Johana Díaz, Laura Milena Betrán, Francy Liliana Hernández, Carlos Javier Alméciga Díaz, Luis Alejandro Barrera
Format:	Artigo
Idioma:	Inglês
Publicat:	Pontificia Universidad Javeriana 2016-08-01
Col·lecció:	Universitas Scientiarum
Matèries:	β-N-acetylhexosaminidases; characterization; Pichia pastoris; recombinant hexosaminidases; Sandhoff disease β-N-acetylhexosaminidases characterization Pichia pastoris recombinant hexosaminidases Sandhoff disease Tay Sachs disease.
Accés en línia:	http://revistas.javeriana.edu.co/index.php/scientarium/article/view/15736
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