Chitinase-1 inhibition attenuates metabolic dysregulation and restores homeostasis in MASH animal models

BackgroundOATD-01 is a chitinase-1 (CHIT1) inhibitor, reducing inflammation and fibrosis in animal models where chronic inflammation leads to tissue remodeling. CHIT1, predominantly secreted by macrophages, is overexpressed in metabolic dysfunction-associated steatohepatitis (MASH).Methods and resul...

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मुख्य लेखकों:	Katarzyna Drzewicka, Katarzyna M. Głuchowska, Michal Mlącki, Bartłomiej Hofman, Irina Tuszyńska, Tristram A. J. Ryan, Katarzyna Piwowar, Bartosz Wilczyński, Dorota Dymkowska, Marcin M. Grzybowski, Barbara Dymek, Tomasz Rejczak, Kamil Lisiecki, Adam Gołębiowski, Adam Jagielski, Angelika Muchowicz, Dylan Ryan, Krzysztof Zabłocki, Luke A. J. O’Neill, Zbigniew Zasłona
स्वरूप:	Artigo
भाषा:	Inglês
प्रकाशित:	Frontiers Media S.A. 2025-05-01
श्रृंखला:	Frontiers in Immunology
विषय:	chitinase 1 OATD-01 MASH fibrosis inflammation macrophage
ऑनलाइन पहुंच:	https://www.frontiersin.org/articles/10.3389/fimmu.2025.1544973/full
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