Persistent DNA damage triggers activation of the integrated stress response to promote cell survival under nutrient restriction
Abstract Background Base-excision repair (BER) is a central DNA repair mechanism responsible for the maintenance of genome integrity. Accordingly, BER defects have been implicated in cancer, presumably by precipitating cellular transformation through an increase in the occurrence of mutations. Hence...
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| Автори: | , , , , , |
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| Формат: | Artigo |
| Мова: | Inglês |
| Опубліковано: |
BMC
2020-03-01
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| Серія: | BMC Biology |
| Предмети: | |
| Онлайн доступ: | http://link.springer.com/article/10.1186/s12915-020-00771-x |
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