Persistent DNA damage triggers activation of the integrated stress response to promote cell survival under nutrient restriction

Abstract Background Base-excision repair (BER) is a central DNA repair mechanism responsible for the maintenance of genome integrity. Accordingly, BER defects have been implicated in cancer, presumably by precipitating cellular transformation through an increase in the occurrence of mutations. Hence...

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Ngā kaituhi matua:	Elena Clementi, Larissa Inglin, Erin Beebe, Corina Gsell, Zuzana Garajova, Enni Markkanen
Hōputu:	Artigo
Reo:	Inglês
I whakaputaina:	BMC 2020-03-01
Rangatū:	BMC Biology
Ngā marau:	DNA repair DNA base-excision repair DNA base damage DNA single-strand breaks DNA double-strand breaks DNA damage response
Urunga tuihono:	http://link.springer.com/article/10.1186/s12915-020-00771-x
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