Astrocytic and Neuronal Apolipoprotein E Isoforms Differentially Affect Neuronal Excitability

Synaptic changes and neuronal network dysfunction are among the earliest changes in Alzheimer’s disease (AD). Apolipoprotein E4 (ApoE4), the major genetic risk factor in AD, has been shown to be present at synapses and to induce hyperexcitability in mouse knock-in brain regions vulnerable to AD. Apo...

Popoln opis

Bibliografske podrobnosti

Principais autores:	Sabine C. Konings, Laura Torres-Garcia, Isak Martinsson, Gunnar K. Gouras
Format:	Artigo
Jezik:	Inglês
Izdano:	Frontiers Media S.A. 2021-09-01
Serija:	Frontiers in Neuroscience
Teme:	Apolipoprotein E Alzheimer’s disease synapse neuron astrocyte amyloid
Online dostop:	https://www.frontiersin.org/articles/10.3389/fnins.2021.734001/full
Oznake:	Označite Brez oznak, prvi označite!