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Astrocytic and Neuronal Apolipoprotein E Isoforms Differentially Affect Neuronal Excitability

Synaptic changes and neuronal network dysfunction are among the earliest changes in Alzheimer’s disease (AD). Apolipoprotein E4 (ApoE4), the major genetic risk factor in AD, has been shown to be present at synapses and to induce hyperexcitability in mouse knock-in brain regions vulnerable to AD. Apo...

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Principais autores: Sabine C. Konings, Laura Torres-Garcia, Isak Martinsson, Gunnar K. Gouras
פורמט: Artigo
שפה:Inglês
יצא לאור: Frontiers Media S.A. 2021-09-01
סדרה:Frontiers in Neuroscience
נושאים:
Apolipoprotein E
Alzheimer’s disease
synapse
neuron
astrocyte
amyloid
גישה מקוונת:https://www.frontiersin.org/articles/10.3389/fnins.2021.734001/full
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