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IDO-Mediated Immune and Metabolic Dysregulation in Schwann Cells Exposed to <i>Mycobacterium leprae</i>

Leprosy is a chronic infectious disease that targets the peripheral nervous system, leading to peripheral neuropathy. <i>Mycobacterium leprae</i> primarily infects Schwann cells, adipocytes, and macrophages, altering their metabolism and gene expression. This study investigates the metabolic interac...

Ausführliche Beschreibung

Gespeichert in:
Hauptverfasser: Atta Ur Rahman, Raíssa Couto Santana, Mylena Masseno de Pinho Pereira, Claudia Luciana dos Santos Moura, Débora Santos da Silva, Otto Castro Araujo, Thyago Leal-Calvo, Isabela Espasandin, Tatiana Pereira da Silva, Euzenir Nunes Sarno, Bruno Jorge de Andrade Silva, Rubem Sadok Figueiredo Menna-Barreto, Márcia Maria Jardim, Cristiana Santos de Macedo, Flávio Alves Lara, Roberta Olmo Pinheiro
Format: Artigo
Sprache:Inglês
Veröffentlicht: MDPI AG 2025-10-01
Schriftenreihe:Cells
Schlagworte:
<i>Mycobacterium leprae</i>
Schwann cells
Indoleamine 2,3 Dioxygenase (IDO)
kynurenine pathway
Online-Zugang:https://www.mdpi.com/2073-4409/14/19/1550
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