Structure of an open KATP channel reveals tandem PIP2 binding sites mediating the Kir6.2 and SUR1 regulatory interface

Abstract ATP-sensitive potassium (KATP) channels, composed of four pore-lining Kir6.2 subunits and four regulatory sulfonylurea receptor 1 (SUR1) subunits, control insulin secretion in pancreatic β-cells. KATP channel opening is stimulated by PIP2 and inhibited by ATP. Mutations that increase channe...

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Hlavní autoři:	Camden M. Driggers, Yi-Ying Kuo, Phillip Zhu, Assmaa ElSheikh, Show-Ling Shyng
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Nature Portfolio 2024-03-01
Edice:	Nature Communications
On-line přístup:	https://doi.org/10.1038/s41467-024-46751-5
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