An integrative approach to studying sphingolipid metabolism reveals p53 as a master regulator of the pathway

Sphingolipids (SPLs) are bioactive lipids playing vital functions in cellular stress responses. The tumor suppressor p53 has been implicated in regulating a few specific SPL enzymes; however, a comprehensive understanding of p53’s overall impact on SPL metabolism is lacking. Here, we employed an int...

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Detalhes bibliográficos

Principais autores:	Botheina Ghandour, Saif Amin, Nihal Medatwal, Allen H. Lee, Gui-Qin Yu, Andrew E. Resnick, Sam B. Chiappone, Christopher J. Clarke, Daniel Canals, Yusuf A. Hannun, Chiara Luberto
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Elsevier 2026-03-01
coleção:	Journal of Lipid Research
Assuntos:	sphingolipids flux analysis lipidomics p53 doxorubicin in situ enzymatic activity
Acesso em linha:	http://www.sciencedirect.com/science/article/pii/S0022227526000209
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