An integrative approach to studying sphingolipid metabolism reveals p53 as a master regulator of the pathway

Sphingolipids (SPLs) are bioactive lipids playing vital functions in cellular stress responses. The tumor suppressor p53 has been implicated in regulating a few specific SPL enzymes; however, a comprehensive understanding of p53’s overall impact on SPL metabolism is lacking. Here, we employed an int...

Szczegółowa specyfikacja

Opis bibliograficzny

Główni autorzy:	Botheina Ghandour, Saif Amin, Nihal Medatwal, Allen H. Lee, Gui-Qin Yu, Andrew E. Resnick, Sam B. Chiappone, Christopher J. Clarke, Daniel Canals, Yusuf A. Hannun, Chiara Luberto
Format:	Artigo
Język:	Inglês
Wydane:	Elsevier 2026-03-01
Seria:	Journal of Lipid Research
Hasła przedmiotowe:	sphingolipids flux analysis lipidomics p53 doxorubicin in situ enzymatic activity
Dostęp online:	http://www.sciencedirect.com/science/article/pii/S0022227526000209
Etykiety:	Dodaj etykietę Nie ma etykietki, Dołącz pierwszą etykiete!