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Mutations of PTPN11 are rare in adult myeloid malignancies

The PTPN11 gene encodes the phospho-tyrosyine phosphatase protein SHP-2. Constitutional mutations of this gene are involved in Noonan's syndrome, a developmental disorder in which children have a predisposition to develop a myeloid disorder called juvenile myelomonocytic leukemia. Recently, studies...

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Autori principali: L Hugues, H Cave, N Philippe, S Pereira, P Fenaux, C Preudhomme
Natura: Artigo
Lingua:Inglês
Pubblicazione: Ferrata Storti Foundation 2005-01-01
Serie:Haematologica
Accesso online:https://haematologica.org/article/view/3565
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