Inhibiting cycloxygenase and ornithine decarboxylase by diclofenac and alpha-difluoromethylornithine blocks cutaneous SCCs by targeting Akt-ERK axis.

Non-melanoma skin cancer (NMSC) is the most common type of skin cancer in Caucasian populations. Its increasing incidence has been a major public health concern. Elevated expressions of ODC and COX-2 are associated with both murine and human NMSCs. Inhibition of these molecular targets singly employ...

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Autores principales:	Aadithya Arumugam, Zhiping Weng, Sarang S Talwelkar, Sandeep C Chaudhary, Levy Kopelovich, Craig A Elmets, Farrukh Afaq, Mohammad Athar
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	Public Library of Science (PLoS) 2013-01-01
Colección:	PLoS ONE
Acceso en línea:	https://doi.org/10.1371/journal.pone.0080076
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