Disruption of the NDC80–Nek2 axis suppresses glioblastoma stemness and enhances therapeutic efficacy

Abstract Background Glioblastoma (GBM), the most aggressive primary brain tumor, demonstrates resistance to standard therapies, primarily due to the presence of GBM stem cells (GSCs), the mechanisms of which remain poorly understood. Methods To identify therapeutic targets for GSCs, we utilized mult...

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Autors principals:	Rui Niu, Rui Gong, Wanjun Wang, Meichen Liu, Cheng-Xiong Xu, Hong-Lin Liu, Lingling Lin, Tao Jiang, Jinlong Yin
Format:	Artigo
Idioma:	Inglês
Publicat:	BMC 2026-02-01
Col·lecció:	Journal of Translational Medicine
Matèries:	Glioblastoma stem cell Cell cycle NDC80 Nek2 Stemness
Accés en línia:	https://doi.org/10.1186/s12967-026-07829-4
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