Cheminformatics approach to identify andrographolide derivatives as dual inhibitors of methyltransferases (nsp14 and nsp16) of SARS-CoV-2

Abstract The Covid-19 pandemic outbreak has accelerated tremendous efforts to discover a therapeutic strategy that targets severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) to control viral infection. Various viral proteins have been identified as potential drug targets, however, to date,...

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Hauptverfasser:	Jobin Thomas, Anupam Ghosh, Shivendu Ranjan, Jitendra Satija
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Nature Portfolio 2024-04-01
Schriftenreihe:	Scientific Reports
Schlagworte:	Covid-19 Andrographolide Drug discovery Natural compounds nsp14 nsp16
Online-Zugang:	https://doi.org/10.1038/s41598-024-58532-7
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