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Impacts of immune checkpoint inhibitors use on the HIV reservoir are linked to provirus sequences but not integration sites

Abstract Antibodies to programmed cell death 1 (PD-1), Programmed death-ligand 1 (PDL-1) and Cytotoxic-T-lymphocyte-associated protein 4 (CTLA-4) can revert HIV latency and enhance anti-HIV cytotoxic response but their impact on HIV proviral sequences and integration landscape in people with HIV (PW...

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Uloženo v:
Hlavní autoři: Vincent Guiraud, Antoine Fauchois, Cathia Soulie, Valentin Leducq, Marianne Veyri, Lambert Assoumou, David Boutolleau, Dominique Costagliola, Olivier Lambotte, Jean-Philippe Spano, Valérie Pourcher, Anne-Geneviève Marcelin, Vincent Calvez
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Portfolio 2025-08-01
Edice:Scientific Reports
Témata:
HIV cure
Shock and kill
Integration site
Viral reservoir
CTLA-4
PD-1
On-line přístup:https://doi.org/10.1038/s41598-025-15349-2
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