Impacts of immune checkpoint inhibitors use on the HIV reservoir are linked to provirus sequences but not integration sites

Abstract Antibodies to programmed cell death 1 (PD-1), Programmed death-ligand 1 (PDL-1) and Cytotoxic-T-lymphocyte-associated protein 4 (CTLA-4) can revert HIV latency and enhance anti-HIV cytotoxic response but their impact on HIV proviral sequences and integration landscape in people with HIV (PW...

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Detalhes bibliográficos

Principais autores:	Vincent Guiraud, Antoine Fauchois, Cathia Soulie, Valentin Leducq, Marianne Veyri, Lambert Assoumou, David Boutolleau, Dominique Costagliola, Olivier Lambotte, Jean-Philippe Spano, Valérie Pourcher, Anne-Geneviève Marcelin, Vincent Calvez
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Nature Portfolio 2025-08-01
coleção:	Scientific Reports
Assuntos:	HIV cure Shock and kill Integration site Viral reservoir CTLA-4 PD-1
Acesso em linha:	https://doi.org/10.1038/s41598-025-15349-2
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