Cell type-specific induction of ferroptosis to boost antitumor immunity
Traditional ferroptosis activators typically suppress antitumor immunity. Our discovery shows that N6F11, a small molecule compound, can selectively induce ferroptosis by targeting TRIM25-mediated GPX4 degradation in cancer cells while sparing immune cells. This breakthrough establishes a safe and e...
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| Principais autores: | , , , |
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| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
Taylor & Francis Group
2023-12-01
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| 叢編: | OncoImmunology |
| 主題: | |
| 在線閱讀: | https://www.tandfonline.com/doi/10.1080/2162402X.2023.2282252 |
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