Exosomal ACADM sensitizes gemcitabine-resistance through modulating fatty acid metabolism and ferroptosis in pancreatic cancer

Abstract This study aimed to evaluate the potential of exosomes from cancer cells to predict chemoresistance in pancreatic cancer (PC) and explore the molecular mechanisms through RNA-sequencing and mass spectrometry. We sought to understand the connection between the exosomal Medium-chain acyl-CoA...

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Auteurs principaux:	Yuhan Yang, Haitao Gu, Kundong Zhang, Zengya Guo, Xiaofeng Wang, Qingyun Wei, Ling Weng, Xuan Han, Yan Lv, Meng Cao, Peng Cao, Chen Huang, Zhengjun Qiu
Format:	Artigo
Langue:	Inglês
Publié:	BMC 2023-08-01
Collection:	BMC Cancer
Sujets:	Exosomes Lipid metabolism Ferroptosis Pancreatic cancer Biomarker Gemcitabine
Accès en ligne:	https://doi.org/10.1186/s12885-023-11239-w
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