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Exosomal ACADM sensitizes gemcitabine-resistance through modulating fatty acid metabolism and ferroptosis in pancreatic cancer

Abstract This study aimed to evaluate the potential of exosomes from cancer cells to predict chemoresistance in pancreatic cancer (PC) and explore the molecular mechanisms through RNA-sequencing and mass spectrometry. We sought to understand the connection between the exosomal Medium-chain acyl-CoA...

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Autori principali: Yuhan Yang, Haitao Gu, Kundong Zhang, Zengya Guo, Xiaofeng Wang, Qingyun Wei, Ling Weng, Xuan Han, Yan Lv, Meng Cao, Peng Cao, Chen Huang, Zhengjun Qiu
Natura: Artigo
Lingua:Inglês
Pubblicazione: BMC 2023-08-01
Serie:BMC Cancer
Soggetti:
Exosomes
Lipid metabolism
Ferroptosis
Pancreatic cancer
Biomarker
Gemcitabine
Accesso online:https://doi.org/10.1186/s12885-023-11239-w
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