Noncoding variation near UBE2E2 orchestrates cardiometabolic pathophenotypes through polygenic effectors

Mechanisms underpinning signals from genome-wide association studies remain poorly understood, particularly for noncoding variation and for complex diseases such as type 2 diabetes mellitus (T2D) where pathogenic mechanisms in multiple different tissues may be disease driving. One approach is to stu...

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Autores principales:	Yang Zhang, Natalie L. David, Tristan Pesaresi, Rosemary E. Andrews, G.V. Naveen Kumar, Hongyin Chen, Wanning Qiao, Jinzhao Yang, Kareena Patel, Tania Amorim, Ankit X. Sharma, Silvia Liu, Matthew L. Steinhauser
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	American Society for Clinical investigation 2025-01-01
Colección:	JCI Insight
Materias:	Endocrinology Genetics
Acceso en línea:	https://doi.org/10.1172/jci.insight.184140
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