Hyperphosphorylated Human Tau Accumulates at the Synapse, Localizing on Synaptic Mitochondrial Outer Membranes and Disrupting Respiration in a Mouse Model of Tauopathy

Neurogenerative disorders, such as Alzheimer’s disease (AD), represent a growing public health challenge in aging societies. Tauopathies, a subset of neurodegenerative disorders that includes AD, are characterized by accumulation of fibrillar and hyperphosphorylated forms of microtubule-associated p...

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Principais autores:	Andrew J. Trease, Joseph W. George, Nashanthea J. Roland, Eliezer Z. Lichter, Katy Emanuel, Steven Totusek, Howard S. Fox, Kelly L. Stauch
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Frontiers Media S.A. 2022-03-01
coleção:	Frontiers in Molecular Neuroscience
Assuntos:	aging bioenergetics proteomics synaptic mitochondria tau phosphorylation
Acesso em linha:	https://www.frontiersin.org/articles/10.3389/fnmol.2022.852368/full
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