Biological properties of α-actinin-2 and its role and mechanisms in disease development

α-Actinin-2 (encoded by the ACTN2 gene) is a critical cytoskeletal protein predominantly expressed in skeletal and cardiac muscle, where it anchors actin filaments to the sarcomeric Z-disk. While its structural role is well-established, emerging evidence increasingly implicates ACTN2 dysfunction in...

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Detalhes bibliográficos

Principais autores:	Juan Meng, Shu-qiong Xu, Qi Deng, Ling-ling Jiang, Dan-Ping Huang, Qing-song Wang, Yong-Kang Wu
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Frontiers Media S.A. 2026-04-01
Colecção:	Frontiers in Physiology
Assuntos:	ACTN2 biomarker cardiomyopathy sarcomere therapeutic target α-actinin-2
Acesso em linha:	https://www.frontiersin.org/articles/10.3389/fphys.2026.1794324/full
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