Optimization of expression, purification and secretion of functional recombinant human growth hormone in Escherichia coli using modified staphylococcal protein a signal peptide

Abstract Background Human Growth Hormone (hGH) is a glycoprotein released from the pituitary gland. Due to the wide range of effects in humans, any disruption in hGH secretion could have serious consequences. This highlights the clinical importance of hGH production in the treatment of different dis...

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Detalhes bibliográficos

Principais autores:	Garshasb Rigi, Amin Rostami, Habib Ghomi, Gholamreza Ahmadian, Vasiqe Sadat Mirbagheri, Meisam Jeiranikhameneh, Majid Vahed, Sahel Rahimi
Formato:	Artigo
Idioma:	Inglês
Publicado em:	BMC 2021-08-01
coleção:	BMC Biotechnology
Assuntos:	Sec pathway Recombinant hGH SpA signal peptide Secretion
Acesso em linha:	https://doi.org/10.1186/s12896-021-00701-x
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