Optimization of expression, purification and secretion of functional recombinant human growth hormone in Escherichia coli using modified staphylococcal protein a signal peptide

Abstract Background Human Growth Hormone (hGH) is a glycoprotein released from the pituitary gland. Due to the wide range of effects in humans, any disruption in hGH secretion could have serious consequences. This highlights the clinical importance of hGH production in the treatment of different dis...

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Autors principals:	Garshasb Rigi, Amin Rostami, Habib Ghomi, Gholamreza Ahmadian, Vasiqe Sadat Mirbagheri, Meisam Jeiranikhameneh, Majid Vahed, Sahel Rahimi
Format:	Artigo
Idioma:	Inglês
Publicat:	BMC 2021-08-01
Col·lecció:	BMC Biotechnology
Matèries:	Sec pathway Recombinant hGH SpA signal peptide Secretion
Accés en línia:	https://doi.org/10.1186/s12896-021-00701-x
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