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MELK Inhibition Effectively Suppresses Growth of Glioblastoma and Cancer Stem-Like Cells by Blocking AKT and FOXM1 Pathways

Glioblastoma multiforme (GBM) is a devastating disease yet no effective drug treatment has been established to date. Glioblastoma stem-like cells (GSCs) are insensitive to treatment and may be one of the reasons for the relapse of GBM. Maternal embryonic leucine zipper kinase gene (MELK) plays an im...

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Wedi'i Gadw mewn:
Prif Awduron: Xu Zhang, Jie Wang, Yifeng Wang, Guanzheng Liu, Huan Li, Jiefeng Yu, Runqiu Wu, Jun Liang, Rutong Yu, Xuejiao Liu
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Frontiers Media S.A. 2021-01-01
Cyfres:Frontiers in Oncology
Pynciau:
glioblastoma multiforme
glioblastoma stem-like cells
maternal embryonic leucine-zipper kinase
OTSSP167
targeted therapy
Mynediad Ar-lein:https://www.frontiersin.org/articles/10.3389/fonc.2020.608082/full
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