Computational identification of Moracin G and Isolonchocarpin as potent MELK inhibitors for anticancer drug discovery
Abstract Maternal embryonic leucine zipper kinase (MELK) is a promising therapeutic target in cancer due to its overexpression in aggressive tumors and role in cell survival, proliferation, and therapy resistance. No MELK inhibitors are currently FDA-approved, so identifying potential leads is neces...
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| Główni autorzy: | , , , |
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| Format: | Artigo |
| Język: | Inglês |
| Wydane: |
Nature Portfolio
2025-12-01
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| Seria: | Scientific Reports |
| Hasła przedmiotowe: | |
| Dostęp online: | https://doi.org/10.1038/s41598-025-29868-5 |
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