Fluxomics reveals cellular and molecular basis of increased renal ammoniagenesis

Abstract The kidney plays a critical role in excreting ammonia during metabolic acidosis and liver failure. The mechanisms behind this process have been poorly explored. The present study combines results of in vivo experiments of increased total ammoniagenesis with systems biology modeling, in whic...

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Hlavní autoři:	Liliane Mpabanzi, Jessica Wainwright, Bas Boonen, Hans van Eijk, Dipok Dhar, Esther Karssemeijer, Cees H. C. Dejong, Rajiv Jalan, Jean-Marc Schwartz, Steven W. M. Olde Damink, Zita Soons
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Nature Portfolio 2022-12-01
Edice:	npj Systems Biology and Applications
On-line přístup:	https://doi.org/10.1038/s41540-022-00257-2
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