In-Depth Comparison of Adeno-Associated Virus Containing Fractions after CsCl Ultracentrifugation Gradient Separation

Recombinant adeno-associated viruses (rAAVs) play a pivotal role in the treatment of genetic diseases. However, current production and purification processes yield AAV-based preparations that often contain unwanted empty, partially filled or damaged viral particles and impurities, including residual...

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Autors principals:	Mojca Janc, Kaja Zevnik, Ana Dolinar, Tjaša Jakomin, Maja Štalekar, Katarina Bačnik, Denis Kutnjak, Magda Tušek Žnidarič, Lorena Zentilin, Dmitrii Fedorov, David Dobnik
Format:	Artigo
Idioma:	Inglês
Publicat:	MDPI AG 2024-07-01
Col·lecció:	Viruses
Matèries:	recombinant adeno-associated viruses (rAAVs) CsCl ultracentrifugation gradient analytical methods digital droplet PCR (ddPCR) transmission electron microscopy (TEM) analytical ultracentrifugation (AUC)
Accés en línia:	https://www.mdpi.com/1999-4915/16/8/1235
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