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Upstream open reading frames located in the leader of protein kinase Mζ mRNA regulate its translation

For protein synthesis that occurs locally in dendrites, the translational control mechanisms are much more important for neuronal functioning than the transcription levels. Here, we show that uORFs (upstream open reading frames) in the 5’ untranslated region (5’UTR) play a critical role in regulatio...

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Principais autores: Natalia V Bal, Denis Susorov, Ekaterina Chesnokova, Artem Kasianov, Tatiana Mikhailova, Elena Alkalaeva, Pavel M. Balaban, Peter Kolosov
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2016-10-01
coleção:Frontiers in Molecular Neuroscience
Assuntos:
translational control
local protein synthesis
UORF
PKMζ
eIF2a phosphorylation
Acesso em linha:http://journal.frontiersin.org/Journal/10.3389/fnmol.2016.00103/full
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