Prevalence and impact of molecular variation in the three-prime repair exonuclease 1 TREX1 and its implications for oncology

Abstract Background The three-prime repair exonuclease 1, TREX1, degrades cytosolic DNA to prevent aberrant immune activation. Its inactivation results in DNA accumulation in the cytosol and induction of the cGAS-STING DNA sensing pathway, interferon signaling, and inflammation. Germline pathogenic...

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Bibliografiset tiedot

Päätekijät:	Marwa Shekfeh, Mariam M. Konaté, Julia Krushkal
Aineistotyyppi:	Artigo
Kieli:	Inglês
Julkaistu:	BMC 2025-06-01
Sarja:	Human Genomics
Aiheet:	TREX1 Sequence variant Copy number alteration Innate immunity Cancer Autoimmune disease
Linkit:	https://doi.org/10.1186/s40246-025-00785-y
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