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Therapeutic Approaches Targeting PAX3-FOXO1 and Its Regulatory and Transcriptional Pathways in Rhabdomyosarcoma

Rhabdomyosarcoma (RMS) is a family of soft tissue cancers that are related to the skeletal muscle lineage and predominantly occur in children and young adults. A specific chromosomal translocation t(2;13)(q35;q14) that gives rise to the chimeric oncogenic transcription factor PAX3-FOXO1 has been ide...

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Principais autores: Thanh Hung Nguyen, Frederic G. Barr
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI AG 2018-10-01
coleção:Molecules
Assuntos:
rhabdomyosarcoma
oncogenic transformation
gene fusion
transcription factor
targeted therapy
Acesso em linha:https://www.mdpi.com/1420-3049/23/11/2798
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