Higher-Order Structure of Adeno-Associated Virus Serotype 8 by Hydrogen/Deuterium Exchange Mass Spectrometry

The higher-order structure (HOS) is a critical quality attribute of recombinant adeno-associated viruses (rAAVs). Evaluating the HOS of the entire rAAV capsid is challenging because of the flexibility and/or less folded nature of the VP1 unique (VP1u) and VP1/VP2 common regions, which are structural...

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Principais autores:	Tomohiko Ikeda, Yuki Yamaguchi, Hiroaki Oyama, Aoba Matsushita, Yasuo Tsunaka, Mitsuko Fukuhara, Tetsuo Torisu, Susumu Uchiyama
Formato:	Artigo
Idioma:	Inglês
Publicado em:	MDPI AG 2024-04-01
coleção:	Viruses
Assuntos:	gene therapy adeno-associated virus hydrogen/deuterium exchange mass spectrometry higher-order structure
Acesso em linha:	https://www.mdpi.com/1999-4915/16/4/585
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