Thermodynamic Modeling of the Amorphous Solid Dispersion-Water Interfacial Layer and Its Impact on the Release Mechanism

During the dissolution of amorphous solid dispersion (ASD) formulations, the gel layer that forms at the ASD/water interface strongly dictates the release of the active pharmaceutical ingredient (API) and, hence, the dissolution performance. Several studies have demonstrated that the switch of the g...

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Manylion Llyfryddiaeth

Prif Awduron:	Stefanie Dohrn, Samuel O. Kyeremateng, Esther Bochmann, Ekaterina Sobich, Andrea Wahl, Bernd Liepold, Gabriele Sadowski, Matthias Degenhardt
Fformat:	Artigo
Iaith:	Inglês
Cyhoeddwyd:	MDPI AG 2023-05-01
Cyfres:	Pharmaceutics
Pynciau:	amorphous solid dispersion (ASD) drug release phase behavior escape glass transition (eGT) liquid-liquid phase separation (LLPS) PC-SAFT
Mynediad Ar-lein:	https://www.mdpi.com/1999-4923/15/5/1539
Tagiau:	Ychwanegu Tag Dim Tagiau, Byddwch y cyntaf i dagio'r cofnod hwn!